CXCR4 is the primary receptor for feline immunodeciency virus in astrocytes
نویسندگان
چکیده
Feline astrocytes were productively infected with the Crandell feline kidney (CrFK) cell-adapted feline immunodeciency virus (FIV) Petaluma strain in a primary culture. They expressed mRNA of CXCR4, and the FIV infection was blocked by stromal cell-derived factor 1® (SDF-1®), SDF-1 ̄, or the bicyclam AMD3100 in a dose-dependent manner. These observations suggest that, like FIV infection inCrFK cellsand lymphocytes, the virus usesCXCR4 as a primary receptor for infecting astrocytes and this can be a possible natural model for AIDS dementia complex. Journal of NeuroVirology (2001) 7, 487–492.
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